Endocrine Abstracts

Cancer patients now live nearly six times longer after their cancer diagnosis than was the case 40 years ago with the median survival time increasing from one year to six years (Macmillan Cancer Support Nov 2011). Indeed in 2009 it was estimated that around 2 million people were alive in the UK with a cancer diagnosis, rising by 3% a year (Maddams et al. 2009). Whilst most cancer survivors report excellent or good health, recent published evidence indicate that cancer s...

The tumor microenvironment can comprise more than 50% of the tumor mass and includes resident and infiltrative non-tumor cells, as well as extracellular matrix proteins, signaling molecules, and blood and lymph vessels (Balkwill et al., 2012). In recent years, the tumor microenvironment has begun to be considered both a prognostic tool and a therapeutic target (Hui and Chen, 2015). While the existence of the tumor microenvironment is well accepted and described in numerous can...

Several differences have been observed in thyroid function parameters between older and younger individuals. Notably, circulating thyroid stimulating hormone (TSH) levels gradually increase with age, a shift shown to extend to extremely high ages. While clinically abnormal thyroid function parameters have been consistently associated with ill health, the mechanisms underlying mild age-related variations in circulating levels of TSH and thyroid hormones and their health consequ...

Hypercalcemia in hyperthyroidism is usually asymptomatic, and related to a concurrent primary hyperparathyroidism. In this report, we describe a case of symptomatic hypercalcemia secondary to Graves’ disease alone.Case report: A 24-year-old Filipino female presented to the emergency department with generalized weakness, vomiting and abdominal pain. No other symptoms were noted. She was otherwise previously healthy. Family history was unremarkable. ...

It has been shown that miR-107 regulates insulin sensitivity, but its status in severe insulin resistance (IR) patients has not been established. In this study, we investigated the expression of microRNA-107 in the sera from patients with clinically severe IR and its relationships with metabolic characteristics.Methods: The expression of microRNA-107 was detected in the sera of 30 clinically severe IR patients and 24 gender and age-matched control group ...

Background: Increasing numbers of children and adults are surviving cancer and living with the consequences of their disease or its treatment. The commonest long term consequences observed following childhood cancer are endocrine and there is a growing body of evidence indicating that adults treated for malignant disease are also at risk of endocrine dysfunction.Aim: To determine the involvement of Endocrinologists in the management of cancer survivors a...

Thyroid hormones play an important role in all stages of life, including old age. Several differences have been observed in thyroid function parameters with age, including an increase in circulating thyroid stimulating hormone (TSH) levels gradually increase with age. In order to identify determinants of human longevity, the Leiden Longevity Study (LLS) included 421 families with at least two long-lived Caucasian siblings fulfilling the age criteria (men ≥89 years and wo...

Pheochromocytoma (PCC) is a rare neuroendocrine tumor, mainly sporadic, many cases are discovered incidentally by computed tomography or magnetic resonance imaging of the abdomen. Malignancy in pheochromocytoma is difficult to diagnose microscopically. Therefore, only the presence of distant metastases, derived from pleomorphic chromaffin cells, is widely accepted as a criterion of malignancy (1)Case presentation: In March 2016, a 43 year old women prese...

Introduction: The change in thyroid parameters is described in the case of antiepileptic treatment in the pediatric population, due to interferences within the hypothalamo-pituitary-thyroid axis and due to the increase in the rate of hepatic metabolism of thyroid hormones.Case presentation: We present the case of a 10-year-old boy who addressed our outpatient pediatric endocrinology department for endocrine evaluation in the context of weight growth abou...

IntroductionPituitary stalk interruption syndrome (PSIS) is a rare entity characterized by a triad of thin or interrupted pituitary stalk, aplasia or hypoplasia of the anterior pituitary and absent or ectopic posterior pituitary seen on magnetic resonance imaging (MRI). We are presenting the clinical case of a child who presented for short stature.Case presentationWe present the case of a 4 year and 8 months ...